rapid and green synthesis of some benzothiazole-, benzimidazole- and benzoxazole-2-thiol derivatives using copper sulfate in aqueous media

in this study an easy, green, efficient and simple approach is reported for the synthesis of some benzothiazole-, benzimidazole- and benzoxazole-2-thiolderivatives. the proposed approach employs the reaction of corresponding aromatic amine with potassium isopropyl xanthate (z11) in the presence of copper sulfate (cuso4) as a catalyst under conventional heating and ultrasonic irradiation. the advantages of this protocol are: using water and glycerol as green solvents, commercially available precursors, simple work-up, an inexpensive catalyst, high yield and short reaction time.